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Not every study has demonstrated that oral B12 supplementation reduces the risk of deficiency in metformin users, which the researchers indicated may be explained because the dose of 0.6 μg typically found in multivitamin supplements is inadequate for those on metformin treatment in terms of prophylaxis, 56 whereas other studies have found that multivitamin use was associated with reduced risk of deficiency Merck_Exclude Size:1 bottle https://resources.afl.com.au/photo-resources/2019/11/30/8c44dc06-8d4a-455e-ba2d-0376a7b8c5d5/lGzfeHmK.jpg?width=708&height=1062 Cellular and molecular neuropathology of the cuprizone mouse model: Clinical relevance for multiple sclerosis - ScienceDirect

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