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Across various etiologies of acquired SNHL—whether it be the direct toxicity of cisplatin and neomycin, the energy metabolism crisis induced by noise exposure, or the cumulative oxidative damage from aging—these stressors ultimately converge at a common endpoint: the uncontrolled accumulation of lethal lipid peroxides in cochlear hair cells and spiral ganglion neurons
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doi: 10.1074/jbc.272.15.10004
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