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Most ALPS patients are affected by heterozygous germline mutations in the Fas cell surface death receptor gene ( FAS ) via autosomal dominant inheritance (Jackson et al., 1999
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While more severe forms are not all that common, some research estimates that MCAS could “affect up to 17% of the population on a spectrum from very mild to debilitating symptoms.”[ref] Others include very mild symptoms such as allergic rhinitis in the mast cell activation spectrum, which includes up to 30% of the population.[ref]
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