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These data suggest that the genetic features of specific enzymes of the glutathione antioxidant system and their control of oxidative and nitrosative stresses throughout the lifespan highlight their likely involvement in defining the fate of normal aging, particularly in the CNS
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Therefore, to investigate cell-ECM interactions and gain an understanding of their role in diseases such as cancer and fibrosis, it is necessary to develop and apply biomimetic model systems that accurately recapitulate the physiological aspects of the ECM and the cell-ECM interface
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