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Women with fibroids have significantly increased rates of infertility [3], hypertension [4], and depression [5] compared to controls
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Extracellular HMGB1 binds to the receptors (e.g., Toll-like receptor 2 (TLR2), TLR4, and RAGE (receptors for advanced glycation end-products)) of immature DCs which cause DC maturation and cytotoxic T lymphocytes (CTLs) activation (16)
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