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In addition, studies on the role of PCSK9 in different cells involved in at all stages of the plaque have supported that the effect of PCSK9 on atherosclerotic development is beyond the LDLR degradation, and occurs by crosstalking with other molecular mechanisms ranging from the activation of inflammatory pathways to apoptosis of ECs and migration of VSMCs

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The ghrelin receptor is primarily expressed in brain, but lower levels can also be found in certain peripheral organs, such as pancreas, spleen, kidney and adrenal gland [34,35]