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Subsequently, neutrophils predominate at the inflammatory site and represent a significant cell population contributor to the pathology of gout through the release of pro-inflammatory mediators, such as IL-1β, TNF-α, or NETs and proteases [43]
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46 Currently, the South Korea-based biotechnology company, AngioLab Inc., is conducting phase II trials for the use of the anti-angiogenic/anti-MMP drug, ALS-L1023, in treating obesity
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