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The report highlights early metabolic studies, selected clinical trials, and certain double-blind placebo-controlled investigations that examined markers such as: blood sugar regulation insulin sensitivity cholesterol levels impaired glucose tolerance adipose tissue activity fat release and lipolytic activity While these studies generated interest in AOD-9604 as a potential anti-obesity drug candidate , the report stresses that no authority recognizes it as an active treatment for obesity, weight loss, or human use — and emphasizes that it remains designated strictly for research use

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The selectivity argument is that healthy cells do not depend on the FOXO4 and p53 interaction for survival, so blocking it should kill senescent cells preferentially rather than being generally cytotoxic