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The Tf-TfR1 complex is internalized via receptor-mediated endocytosis.58 Within acidic endosomes, Fe 3+ is released from Tf and reduced to Fe 2+ by the ferrireductase six-transmembrane epithelial antigen of the prostate 3 (Steap3).59 Fe 2+ is then transported into the cytoplasm by divalent metal ion transporter-1 (DMT1).60 The Tf-TfR1 complex is recycled back to the membrane
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