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222,227 Signaling pathways linked to AD pathogenesis Neuroinflammatory signaling Several pathological factors in AD, such as Aβ, pro-inflammatory cytokines, and oxidative stress, activate microglia and initiate downstream signaling pathways such as MAPK, NF-κB, and PI3K/Akt

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However, Lactobacillus salivarius inhibited the above signaling pathway and led to attenuated amyloidogenic processes in the gut, suggesting a probable therapeutic target in AD through MGBA [82]