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Interindividual variability in these metabolic pathways is substantial, as shown by Yamamoto et al., who demonstrated that genetic polymorphisms in alcohol dehydrogenase and aldehyde dehydrogenase significantly influence acetaldehyde accumulation and modify susceptibility to ethanol-induced toxicity [28]
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Future efforts must prioritize multi-center trials for safety/PK profiling, biodegradable polymers with tunable degradation, and multi-omics biomarkers for personalized therapy
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