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Proteasome inhibition prevents further degradation of newly formed oxidized proteins and increases protein aggregation formation in cells (Takalo et al., 2013

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Some important risk factors include 5,6 : Older age Family history Unhealthy diet and sedentary lifestyle Smoking Dyslipidemia (imbalanced levels of cholesterol and triglycerides) Hypertension Elevated glucose and insulin levels Chronic kidney disease Obesity High homocysteine levels A range of chronic inflammatory conditions Chronic infections such as human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) It is important to note that a growing proportion of cardiovascular events, including heart attacks, are now occurring in people without well-established risk factors