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However, at variance with protein folding, presently, much less is known on the conformational states available to an aggregating polypeptide chain and on the structural features at the atomic level of the early oligomeric assemblies
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Cagrilintide is an amylin analogue that agonizes amylin receptors (AMY1, AMY2, AMY3) and calcitonin receptors in the hypothalamus and area postrema, promoting satiety and slowing gastric emptying through a mechanism distinct from GLP-1 receptor pathways
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