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However, at the nonpermissive temperature of 25 °C, loss of daf-2 function results in reduced insulin/IGF-1-like signaling, robust DAF-16 hyperactivation, and transition of larval worms into the dauer larval stage 26, 27

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At the same time, mitochondrial Ca 2+ uniporter glutathionylation promotes activation of mitochondrial Ca 2+ import, resulting in the activation of oxidative phosphorylation, but also increasing apoptosis 105