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The preclinical efficacy signals are strong

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At the same time, it is important to remember that the positive effects of the mentioned polyphenols from consuming fruits, vegetables, and olive oil (100 calories/spoon) may be limited if people continue to follow a high-calorie diet that includes unclear amounts of alcoholic beverages, which are major contributors to liver damage, impaired insulin sensitivity, elevated blood glucose levels, and increased insulin concentrations [94,95]