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In vivo magnetic resonance spectroscopy (¹H-MRS) have reveals age-dependent reductions in GSH in metabolically active brain regions, including the hippocampus, posterior cingulate cortex, and frontal cortex [17, 18, 21], regions that are also among the earliest and most severely affected in AD [18, 21]

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Of note Zn concentrations of 100 μM (μmoles L) correspond to 6.53 μg/ml—although these levels are reported in the ECF or synaptic cleft of CNS and cannot be compared directly with serum levels, they are much higher than the upper normative serum Zn level that was previously discussed (1.43 μg/ml) and 100 times more than Zn in CSF