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(2024) reported that in TP53-mutant AML cells, cytarabine and idarubicin combination increase the levels of the p53 and p21 proteins, and upregulated the G2/M-phase cell-cycle checkpoints regulators cdc25c, p-CDK1, and Cyclin b in DTP cells, causing cell cycle arrest in G2/M phase and drug-resistance
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276, 8469–8474 [DOI] [PubMed] [Google Scholar] 39
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