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🧬 The Polyol Pathway in Hyperglycemia — a classic USMLE mechanism with major clinical consequences. When intracellular glucose rises in insulin-independent tissues, aldose reductase converts glucose into sorbitol and consumes NADPH in

This imbalance in lipid metabolism creates a lipotoxic microenvironment, where reactive oxygen species (ROS) are excessively produced due to the oxidation of FFAs, a key factor in driving cellular stress

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