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Conclusions PDT has a measurable impact on survival in unresectable cholangiocarcinoma but requires aggressive stenting posttherapy
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In HD models, striatal Mn accumulation is diminished (including in HD patient-derived neural progenitors and HD mouse striatal cells) and has been linked to impaired XK/Rab11-dependent Mn handling and disrupted Mn-dependent ATM–p53 signaling, with Mn sensitivity varying by lineage and developmental stage 264
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