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This anti-inflammatory response was mechanistically linked to the curcuminoids’ ability to inhibit the expression of toll-like receptors, toll-like receptor-2 (TLR-2) and TLR-4 at both the mRNA and protein levels, which are upstream regulators of NF-κB and MAPK signaling pathways that drive cytokine production (Lee et al., 2022)
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Similarly, GPx4 and GPx7 were found to be overexpressed in HCC tissues and their levels correlate with the malignancy grade [314]
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