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γGT-activated prodrugs and potential nephrotoxicity Gamma-glutamyl transferase being the initial and limiting step in γGT-activated prodrugs processing and because γGT is highly expressed on the luminal surface of the proximal tubules in the kidney, potential nephrotoxicity could have been a limitation in the usage of this class of compound when administered systematically
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However, researchers with active malignancies should avoid use until more data exists
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