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Indeed, depolarization with high K + led to the release of copper into the extracellular space and, from these experiments, it was estimated that the putative concentration of released copper within the synaptic cleft could be as high as 200–250 μM (Kardos et al., 1989)
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Recently, the role of this cell death modality in the pathogenesis of various diseases has garnered increasing attention (Wang et al., 2020)
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