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One of the mechanisms by which bFGF promotes angiogenesis is that it stimulates endothelial cells to secrete collagenases that lead to degradation of the vascular basement membrane, followed by the invasion of surrounding cells into the underlying cytoplasmic matrix and the formation of a capillary network, thereby promoting neovascularization and accelerating the healing of tendon injuries (Thomopoulos et al., 2010)