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J Biol Chem 260(28):15008–15012 [PubMed] [Google Scholar] 86.Crackower M et al (1999) Assignment1 of the SLC25A12 gene coding for the human calcium-binding mitochondrial solute carrier protein aralar to human chromosome 2q24
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5) Unlike the neuropsychiatric disorders, in which Glu-GSH dysregulation primarily reflects a failure of homeostatic defense, cancer cells actively co-opt and amplify the Glu-GSH axis as a pro-survival resource: constitutively elevated GSH biosynthesis, driven by reprogrammed glutamine catabolism and context-dependent transcriptional rewiring, simultaneously fuels proliferation, shields cells from oxidative stress, amplifies mitogenic signaling, and remodels the tumor immune microenvironment
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