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For protocols requiring higher stock concentrations, a small volume of 0.1% acetic acid solution can improve dissolution before dilution into the final experimental buffer

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While more severe forms are not all that common, some research estimates that MCAS could “affect up to 17% of the population on a spectrum from very mild to debilitating symptoms.”[ref] Others include very mild symptoms such as allergic rhinitis in the mast cell activation spectrum, which includes up to 30% of the population.[ref]