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Causes of insomnia may include: stress disruptions to the internal body clock, due to travel or work commitments poor sleep habits, such as an irregular bedtime schedule eating late in the evening mental health conditions, such as anxiety and depression neurodegenerative conditions, such as Alzheimer’s disease neurodevelopmental conditions, such as attention deficit hyperactivity disorder (ADHD) certain medications, such as those for depression, asthma, and high blood pressure sleep-related disorders, such as sleep apnea and restless legs syndrome consuming alcohol, nicotine, and caffeine Deficiencies or higher levels of the following vitamins may impact sleep: Vitamin D Studies indicate vitamin D levels also support pathways that regulate melatonin

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Based on the cholinergic hypothesis of memory formation it was originally proposed that drugs designed to inhibit central and peripheral acetylcholine esterase (AChE), and serve as a muscarinic M2 autoreceptor antagonist, would result in facilitated release of ACh