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Furthermore, in patients with high-risk pulmonary embolism (PE), significant reductions in tricarboxylic acid (TCA) cycle intermediates—including alpha-ketoglutarate, malate, isocitrate, fumarate, and cis-aconitate—have been observed [39]

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Next, we examined whether supplementing with a diet rich in lipids could reverse these reduced triglyceride and weight loss phenotypes