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Sulforaphane also induced S-phase and G2/M-phase cell cycle arrest, enhanced histone acetylation, and up-regulated cell cycle proteins in the prostate cancer cell lines, DU145 and PC-3 (Rutz et al., 2020), suggesting that sulforaphane treatment leads to reduced cell proliferation activity

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In addition, the matrix metalloproteinase, tissue inhibitor of metalloproteinase, mitogen-activated protein kinase, and phosphocarnosin 3 kinase families are positively correlated with the high expression of Piezo1 in the pathological process (Zhou et al., 2020)